Arizona (1-3) at San Francisco (1-3)
7:25 p.m. Thursday, NFL Network, KTVT/Ch. 11
Line: Cardinals by 4
The Cardinals come in as the only team in football to have a top-10 offense, a top-10 defense and a losing record. Quarterback Carson Palmer is only four days removed from a concussion and has been ruled out as Drew Stanton gets the start. The defending NFC West champs are at risk of falling to their second consecutive division foe. The 49ers, led by coach Chip Kelley, have struggled to adapt to his offensive scheme, coming in with the 30th-ranked offense. The 49ers, however, have outscored opponents 45-24 in two home games.